Work

A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally advanced or metastatic solid tumors

Year: 2020

Type: article

Study design: Clinical Trial

Source: Investigational New Drugs

DOI: 10.1007/s10637-020-00975-6

Authors: Geoffrey I. Shapiro, Patricia LoRusso, Daniel C. Cho, Luna Musib, Yibing Yan, Matthew Wongchenko, Ilsung Chang, Premal Patel, Iris T. Chan, Sandra Sanabria-Bohorquez, Raymond D. Meng, Johanna C. Bendell

Institutions: Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, Yale Cancer Center, NYU Langone Health, NYU Langone’s Laura and Isaac Perlmutter Cancer Center, Genentech, Celltrion (South Korea), Sarah Cannon, Tennessee Oncology

Language: English

Topic: Melanoma and MAPK Pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funder: Genentech

OpenAlex ID: W3046734733

FWCI: 0.967

Cites: 32

Cited by: 31

Related to: 10