The Black Seed "Nigella sativa" and Morphine Reinforcing Effects in Place Preference Conditioning
Year: 2009
Type: article
Abstract: The aim of this study was to examine the ability of the volatile oil (V.O.) of Nigella sativa to interact with the effect of morphine in a Place Preference Conditioning procedure.This is based on the findings of a number studies that some of the constituents of Nigella sativa were found to have similar effects as morphine, effects such as its analgesic and its anti-anxiety effects.Additionally, it was suggested that V.O.share with morphine a common site of action on the 5-HT system.Thus, twenty four male Albino Wistar rats were divided into two groups, the first one (the experimental group) was injected with a dose of 30 microgram/kg V.O, before being administered a dose of 5mg/kg of morphine and subjected to four-day conditioning sessions on a Place Preference Conditioning procedure.The second group (the control group) was treated the same except that V.O. was substituted with saline.Results showed that although there was clear conditioning effect for morphine, no interaction was found between V.O. and morphine.Results were discussed in terms of the low V.O.dose used in the present study.
Source: المجلة المصرية للدراسات النفسية
Author: ﻣﺤﻤﺪ ﺟﻌﻔﺮ ﺛﺎﺑﺖ،
Language: Arabic
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3047064640