Year: 2020
Type: article
Abstract: Over the past decades, promising therapies targeting different signaling pathways have emerged. Among these pathways, apoptosis has been well investigated and targeted to design diverse chemotherapies. However, some patients are chemoresistant to these therapies due to compromised apoptotic cell death. Hence, exploring alternative treatments aimed at different mechanisms of cell death seems to be a potential strategy for bypassing impaired apoptotic cell death. Emerging evidence has shown that necroptosis, a caspase-independent form of cell death with features between apoptosis and necrosis, can overcome the predicament of drug resistance. Furthermore, previous studies have also indicated that there is a close correlation between necroptosis and reactive oxygen species (ROS); both necroptosis and ROS play significant roles both under human physiological conditions such as the regulation of inflammation and in cancer biology. Several small molecules used in experiments and clinical practice eliminate cancer cells via the modulation of ROS and necroptosis. The molecular mechanisms of these promising therapies are discussed in detail in this review.
Source: Cancers
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,324
Awards: G2705428261, 4-Phenoxyphenol Derivative as Sensitizer of First-Line Chemotherapy against Hepatocellular Carcinoma Cells, The Role of Usp15-Mediated Deubiquitination and Stabilization of Janus Kinase (Jak)-Stat Pathway in the Progression of Non-Small Cell Lung Cancer, G3654358428, G3993785520, G497937365, G5370115381, The Role of Rna Binding Protein Msi2 in Long-Exposure of Phthalate Dehp Induced Metastasis of Triple Negative Breast Cancer Cells, Investigating the Long-Term Effect of Phthalate on the Epigenetic Aberrations in Breast Cancer Cells, Investigating the Mechanism and Protective Effects of Curcumin Metabolites on Blue Light Illuminated-Retinal Pigment Epithelium, G737106015, The Modulation of Ferroptosis and Apoptosis in Quinoline Compound-Induced Anti-Human Non-Small Cell Lung Cancer Cells and the Immuotherapy, G939887807
OpenAlex ID: W3047082133