Ultrabright and Serum-Stable Squaraine Dyes
Year: 2020
Type: article
Abstract: Highly stable symmetric and asymmetric squaraine fluorophores have been synthesized featuring an internal salt bridge between a quaternary ammonium cation and the central oxycyclobutenolate ring of the chromophore. Some of our newly synthesized symmetric and asymmetric compounds display increased molar absorptivity, quantum yield in serum, and thermal/photochemical stability over previously reported squaraine-based dyes. Consequently, both classes show great promise in resurfacing the normal environment-labile squaraine dyes as novel imaging agents and scaffolds for fluorescence sensing. Furthermore, incorporating a covalent attachment point away from the conjugated system allows for biological tagging applications without disturbing the optimum optical characteristics of the newly designed fluorophore.
Source: Journal of Medicinal Chemistry
Authors: Yogesh Yadav, Eric Owens, Shinsuke Nomura, Takeshi Fukuda, Yoonji Baek, Satoshi Kashiwagi, Hak Soo Choi, Maged Henary
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W3047287486