A data resource from concurrent intracranial stimulation and functional MRI of the human brain
Year: 2020
Type: data-paper
Abstract: Mapping the causal effects of one brain region on another is a challenging problem in neuroscience that we approached through invasive direct manipulation of brain function together with concurrent whole-brain measurement of the effects produced. Here we establish a unique resource and present data from 26 human patients who underwent electrical stimulation during functional magnetic resonance imaging (es-fMRI). The patients had medically refractory epilepsy requiring surgically implanted intracranial electrodes in cortical and subcortical locations. One or multiple contacts on these electrodes were stimulated while simultaneously recording BOLD-fMRI activity in a block design. Multiple runs exist for patients with different stimulation sites. We describe the resource, data collection process, preprocessing using the fMRIPrep analysis pipeline and management of artifacts, and provide end-user analyses to visualize distal brain activation produced by site-specific electrical stimulation. The data are organized according to the brain imaging data structure (BIDS) specification, and are available for analysis or future dataset contributions on openneuro.org including both raw and preprocessed data.
Source: Scientific Data
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,870
Funders: Simons Foundation, Wellcome Trust, Karolinska Institutet, Knut och Alice Wallenbergs Stiftelse, National Institutes of Health, Medical Research Council, Biotechnology and Biological Sciences Research Council, National Health and Medical Research Council, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke
Awards: Noradrenaline and Cognitive Dysfunction - Interrogating the Neglected Symptoms of Parkinson’s disease, G1244906885, G3360707922, The impact of attention on the neuronal mechanisms of adaptation in humans and animals, Causal mapping of emotion networks with concurrent electrical stimulation and fMRI, OpenNeuro: An open archive for analysis and sharing of BRAIN Initiative data, Neuronal mechanisms for extracting communication signals and signalling sequences: From animal models to humans.
OpenAlex ID: W3047458353