Left ventricular mass and myocardial scarring in women with hypertensive disorders of pregnancy
Year: 2020
Type: article
Abstract: Aims Hypertensive disorders of pregnancy (HDP) predict future cardiovascular events. We aim to investigate relations between HDP history and subsequent hypertension (HTN), myocardial structure and function, and late gadolinium enhancement (LGE) scar. Methods and results We evaluated a prospective cohort of women with suspected ischaemia with no obstructive coronary artery disease (INOCA) who underwent stress/rest cardiac magnetic resonance imaging (cMRI) with LGE in the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction study. Self-reported history of pregnancy and HDP (gestational HTN, pre-eclampsia, toxaemia and eclampsia) were collected at enrollment. In our cohort of 346, 20% of women report a history of HDP. HDP history was associated with 3.2-fold increased odds of HTN. Women with a history of both HDP and HTN had higher cMRI measured left ventricular (LV) mass compared with women with HDP only (99.4±2.6 g vs 87.7±3.2 g, p=0.02). While we found a similar frequency of LGE scar, we observed a trend towards increased LGE scar size (5.1±3.4 g vs 8.0±3.4 g, p=0.09) among the women with HDP history compared to women without. Conclusion In a high-risk cohort of women with suspected INOCA, 20% had a history of HDP. Women with HDP history were more likely to develop HTN. Our study demonstrates higher LV mass in women with HDP and concomitant HTN. Although the presence of LGE scar was not different in women with and without HDP history, we observed a trend towards larger scar size in women with HDP. Future studies are needed to better assess the relationship of HDP and cardiac morphology and LGE scarring in a larger cohort of women.
Source: Open Heart
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,391
Funders: U.S. Department of Defense, Amgen, AstraZeneca, Brigham and Women's Hospital, University of Florida, Deutsches Krebsforschungszentrum, Society for Women’s Health Research, Ironwood Pharmaceuticals, Incorporated, Ladies Hospital Aid Society, Cedars-Sinai Medical Center, Adelson Family Foundation, Cytori Therapeutics, Verily Life Sciences, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: G1134269671, G1313999278, G1395047820, G1438650436, G1764559527, Together: Transforming and Translating Discovery to Improve Health, G2058569893, Behavioral Medicine and Cardiovascular Research Training, EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR, G2540502964, G2620772713, G276921238, G2780842915, G2858310133, G2933049717, EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR, ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CENTER, G3206908124, G327285978, UCLA Clinical and Translational Science Institute, CVD protection mechanisms involving ACE2/Ang-(1-7) axis, G3745418417, G3751788867, ISCHEMIC HEART DISEASE IN WOMEN--CLINICAL CENTER, Hypertensive Disorders of Pregnancy: Pathways to Future Cardiovascular Disease, G3914182225, UF Clinical and Translational Science Award, G4144345384, G430456586, G4464624970, G4690476334, G4850166151, G4893300499, Cardiovascular Events in Women's Ischemia Syndrome Evaluation, G591582747, G6138076438, Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment, G6621596241, G6665007911, Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction, G7007650866, Immunologic Basis of Coronary Disease in Women, G7086251139, UFRCC for Cardiovascular Cell Therapy Research Network, Renin Angiotensin for Coronary Microvascular Dysfunction, G754274488, G7824414775, G8399618014, G8664061136, Cardiac Autonomic Function in Women, G9000019314, G9000048965, G9000059892, G9000112759, G9000118442, G9000119693, UCLA Clinical and Translational Science Institute, G950221744
OpenAlex ID: W3047633167