Potential Test of Nephropathy Sonchus arvensis L. Leaves on Male Rats (Rattus norvegicus) Diabetes Mellitus
Year: 2020
Type: article
Abstract: This study aims to determine the type of secondary metabolites compounds of the ethanol Sonchus arvensis L leaves extract, the effect of ethanol Sonchus arvensis L leaves extracts the levels of blood glucose and a histopathology picture male white rat induced by streptozotocin. This study used 30 males white rats which were divided into 6 groups, namely the control of normal, negative control, positive control, doses of 200, 300 and 400 mg/kg BW. Results of the study showed that the ethanol Sonchus arvensis L. leaves extracts contained compounds of alkaloids, flavonoids, phenols, saponins and tannins. Sonchus arvensis L ethanol extract at a dose of 300 mg/kg BW is an effective dose in reducing blood glucose levels with an average value of decreasing blood glucose levels 101.6 mg / dL and has an effect on the regeneration of renal tubular cells with an effective dose is 300 mg / kg body weight with an average damage value of 0.28.
Source: Pharmacognosy Journal
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3047859124