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Taking the brake off the immune system: Hypotheses, trials, tribulations, and the evolving discipline of clinical immunopharmacology

Year: 2020

Type: editorial

Abstract: Taking the brake off the immune system: Hypotheses, trials, tribulations, and the evolving discipline of clinical immunopharmacologyThe immuno-oncology discipline has arisen out of the development of the "personalized medicine" era, where drugs were discovered and developed to bind to specific targets integral to cell growth and division.In the tumour micro-environment, the dominant immunosuppressive influences enable cancer cells to evade normal immune surveillance.Defining the cellular and molecular basis of this "hiding from immune surveillance" has been a key scientific goal of biologists and immunologists.The scientific understanding of the interaction between immune effector cells and tumour tissue has led to the development of drugs that enhance the body's immune surveillance systems to promote malignant cell killing.

Source: British Journal of Clinical Pharmacology

DOI: 10.1111/bcp.14481

Authors: Jennifer H. Martin, Lionel D. Lewis

Institutions: University of Newcastle Australia, Dartmouth College, Dartmouth Cancer Center

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W3048217206

Cites: 15

Cited by: 3

Related to: 10