Work

Cell interactions in the bone marrow microenvironment affecting myeloid malignancies

Year: 2020

Type: article

Abstract: The bone marrow is a complex tissue in which heterogeneous populations of stromal cells interact with hematopoietic cells to dynamically respond to organismal needs in defense, hemostasis, and oxygen delivery. Physiologic challenges modify stromal/hematopoietic cell interactions to generate changes in blood cell production. When either stroma or hematopoietic cells are impaired, the system distorts. The distortions associated with myeloid malignancy are reviewed here and may provide opportunities for therapeutic intervention.

Source: Blood Advances

DOI: 10.1182/bloodadvances.2020002127

Authors: Konstantinos D. Kokkaliaris, David T. Scadden

Institutions: Harvard University, Massachusetts General Hospital, Harvard Stem Cell Institute

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,800