Year: 2020
Type: review
Abstract: Arthropod-borne viruses or arbovirus, are most commonly associated with acute infections, resulting on various symptoms ranging from mild fever to more severe disorders such as hemorrhagic fever. Moreover, some arboviral infections can be associated with important neuroinflammation that can trigger neurological disorders including encephalitis, paralysis, ophthalmological impairments, or developmental defects, which in some cases, can lead to long-term defects of the central nervous system (CNS). This is well illustrated in Zika virus-associated congenital brain malformations but also in West Nile virus-induced synaptic dysfunctions that can last well beyond infection and lead to cognitive deficits. Here, we summarize clinical and mechanistic data reporting on cognitive disturbances triggered by arboviral infections, which may highlight growing public health issues spanning the five continents.
Source: Journal of Neuroinflammation
Authors: Marion Clé, Patrick Eldin, Laurence Briant, Annie Lannuzel, Yannick Simonin, Philippe Van de Perre, André Cabié, Sara Salinas
Institutions: Inserm, Université de Montpellier, Établissement Français du Sang, Centre National de la Recherche Scientifique, Institut de Recherche en Infectiologie de Montpellier, Sorbonne Université, Centre Hospitalier Universitaire Pointe-à-Pitre, Institut du Cerveau, Centre d'Investigation Clinique Antilles Guyane, Université des Antilles, Centre Hospitalier Universitaire de Montpellier, Centre Hospitalier Universitaire de Martinique
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,890
OpenAlex ID: W3048695505