Circulating Progenitor Cells in Patients With Coronary Artery Disease and Renal Insufficiency
Year: 2020
Type: article
Study design: Observational Study
Abstract: Patients with coronary artery disease and renal insufficiency (RI) (estimated glomerular filtration rate <60 ml/min/1.73 m2) are at an increased risk of cardiovascular events. The contribution of regenerative capacity, measured as circulating progenitor cell (CPC) counts, to this increased risk is unclear. CPCs were enumerated as cluster of differentiation (CD) 45med+ mononuclear cells expressing CD34+, CD133+, CXCR4+ (chemokine [C-X-C motif] receptor 4), and VEGF2R+ (vascular endothelial growth factor receptor 2) epitopes in 1,281 subjects with coronary artery disease (35% with RI). Patients with RI and low ( median) were at a similar risk as those without RI.
Institutions: Emory University, Winship Cancer Institute
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,400
Funders: American Heart Association, Abraham J. and Phyllis Katz Foundation, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences
Awards: Mental Stress Ischemia: Prognosis and Genetic Influences, G1549419526, G196810821, Metabolomics of subclinical and clinical cardiovascular disease, G2425137595, G2646532638, G2881597845, G2982599902, G3633222814, Cell therapy for diabetic peripheral neurovascular complications, BIOMARKERS OF ISCHEMIC OUTCOMES IN SYMPTOMATIC INTRACRANIAL STENOSIS (BIOSIS), Hypertension angiotensin receptor blockers and cognition: effects and mechanism, Microvascular and sensory nerve function in non-Hispanic Blacks and Whites, G4975459456, IMPACT OF HOME-BASED EXERCISE ON METABOLOMICS AND PROGENITOR CELLS IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE, G7222463982, The role of the renin-angiotensin-endothelial pathway in AD, Adverse effects of RBC transfusions: A unifying hypothesis, Genome-wide association study of MI in Caucasians, G9000154236, G9000265748, G9000278369, Emory Specialized Center of Research Excellence (SCORE) on Sex Differences, Georgia Center for Diabetes Translation Research, J. NRSA Training Core
OpenAlex ID: W3048708472