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Behavioral Phenotyping for Down Syndrome in Mice

Year: 2020
Type: article
Abstract: Down syndrome (DS) is the most frequent genetic cause of intellectual disability, characterized by alterations in different behavioral symptom domains: neurodevelopment, motor behavior, and cognition. As mouse models have the potential to generate data regarding the neurological basis for the specific behavioral profile of DS, and may indicate pharmacological treatments with the potential to affect their behavioral phenotype, it is important to be able to assess disease-relevant behavioral traits in animal models in order to provide biological plausibility to the potential findings. The field is at a juncture that requires assessments that may effectively translate the findings acquired in mouse models to humans with DS. In this article, behavioral tests are described that are relevant to the domains affected in DS. A neurodevelopmental behavioral screen, the balance beam test, and the Multivariate Concentric Square Field test to assess multiple behavioral phenotypes and locomotion are described, discussing the ways to merge these findings to more fully understand cognitive strengths and weaknesses in this population. New directions for approaches to cognitive assessment in mice and humans are discussed. © 2020 Wiley Periodicals LLC. Basic Protocol 1: Preweaning neurodevelopmental battery Basic Protocol 2: Balance beam Basic Protocol 3: Multivariate concentric square field test (MCSF).
DOI: 10.1002/cpmo.79
Institutions: Indiana University Indianapolis, Indiana University – Purdue University Indianapolis, Barcelona Institute of Science and Technology, Centre for Genomic Regulation, Universitat Pompeu Fabra, Instituto de Salud Carlos III, Centre for Biomedical Network Research on Rare Diseases
Language: English
Field: Medicine
Open Access status: green
Funders: National Science Foundation, Indiana Clinical and Translational Sciences Institute, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, National Center for Advancing Translational Sciences, Center for International Business Education and Research, University of Illinois at Urbana-Champaign, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1218922180, Indiana Clinical and Translational Sciences Institute, G3061078540, G3196131747, New methods and theories to interrogate organizational principles from single cell to neuronal networks, G7071088190, Development and treatment of skeletal deficits in a Down syndrome mouse model
OpenAlex ID: W3048715393
FWCI: 1.497
Cites: 111
Cited by: 15
Related to: 10