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Long-term exposure to low-intensity environmental noise aggravates age-related hearing loss via disruption of cochlear ribbon synapses.

Year: 2020

Type: article

Abstract: simulation of the excitatory toxicity of glutamate and aging effects, that the activation of NLRP3 inflammasome plays a vital role in the cochlear ribbon synaptic damage. Our results show that long-term exposure to low-intensity environmental noise can lead to hearing loss via the disruption of ribbon synapses, which is caused by an inflammatory reaction. Additionally, environmental noise can further aggravate the progression of ARHL. This study expounded the pathogenesis of the inner ear damage caused by environmental noise exposure and provides a new direction for the prevention and treatment of hearing loss.

Source: PubMed Central

Authors: Shuai Feng, Le Yang, Lian Hui, Yangtuo Luo, Zhengde Du, Wei Xiong, Ke Liu, Xuejun Jiang

Institutions: First Hospital of China Medical University, Guangdong Provincial People's Hospital, Southern Medical University, Capital Medical University, Beijing Friendship Hospital

Language: English

Topic: Hearing, Cochlea, Tinnitus, Genetics

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3048991880

FWCI: 0.616

Cites: 42

Cited by: 21

Related to: 10