Work

Potential mechanism of left ventricular spherical remodeling: association of mitral valve complex-myocardium longitudinal tissue remodeling mismatch

Year: 2020

Type: article

Abstract: Left ventricular (LV) spherical remodeling is associated with poor prognosis and less-effective cardiac performance, which commonly develops in dilated cardiomyopathy. However, its mechanism remains unclear. We hypothesized and subsequently clarified that less mitral valve complex (MVC) tissue longitudinal elongation relative to whole LV myocardial tissue longitudinal elongation is related to disproportionately less LV base longitudinal versus transverse myocardial tissue elongation, constituting spherical remodeling. This study suggests modification of MVC tissue elongation could be potential therapeutic targets.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00279.2020

Authors: Yasufumi Nagata, Mai Iwataki, Yosuke Nabeshima, Soshi Hei, Takeshi Onoue, Atsushi Hayashi, Kyoko Otani, Yuki Tsuda, Masaru Araki, Dae-Hee Kim, Jae-Kwan Song, Akihiro Hayashida, Misako Toki, Toshinori Yuasa, Naoko Mizukami, Yosuke Nishimura, Robert A. Levine, Yutaka Otsuji

Institutions: Harvard University, University of Occupational and Environmental Health Japan, Massachusetts General Hospital, Asan Medical Center, Sakakibara Hospital, Kagoshima University

Language: English

Topic: Cardiovascular Function and Risk Factors

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Japan Society for the Promotion of Science, National Heart, Lung, and Blood Institute

Awards: Potential Mechanism of Left Ventricular Spherical Remodeling: Association of Mitral Valve Complex-Myocardium Longitudinal Tissue Remodeling Mismatch, Improving Mitral Compensation In Ischemic Regurgitation, Improving Mitral Compensation in Ischemic Regurgitation, Treating Ventricle and Valve: New Synergies for Ischemic LV Remodeling with MR

OpenAlex ID: W3049201906

FWCI: 0.155

Cites: 36

Cited by: 2

Related to: 10