Phosphoproteomics reveals the apoptotic regulation of aspirin in the placenta of preeclampsia-like mice.
Year: 2020
Type: article
Abstract: L group comparisons. We demonstrated that apoptosis was increased in the placenta of PE-like mice and was inhibited in the LA group by quantify the apoptosis-positive cells and the protein levels of cleaved caspase 3, 8, and 9. Moreover, the phosphorylation of HSP90β (S254) and GSK3β (Y216) may be a crucial factor in the aspirin-mediated regulation of apoptosis according to protein-protein interaction analysis. This study revealed that apoptosis regulation is a mechanism of aspirin action in PE, particularly in women with over-activated inflammation. The phosphorylation of HSP90β (S254) and GSK3β (Y216) could be the key intervention targets.
Source: PubMed Central
Authors: Jing Huai, Guan-Lin Li, Li Lin, Jing-Mei Ma, Hui-Xia Yang
Institution: Peking University First Hospital
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3049366504