Work

An integrated approach to simulating the vulnerable atherosclerotic plaque

Year: 2020

Type: review

Abstract: In this article, we propose a quantitative framework to describe the evolution of atherosclerotic plaque. We use partial differential equations (PDEs) with macrophages, necrotic cells, oxidized lipids, oxygen concentration, and PDGF as primary variables coupled to a biomechanical model to describe vessel growth. A feature of our method is that it outputs color-coded vessel sections corresponding to regions of the plaque that are necrotic and fibrous, qualitatively similar to images generated by enhanced intravascular ultrasound.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00174.2020

Authors: Navid Mohammad Mirzaei, William S. Weintraub, Pak-Wing Fok

Institutions: University of Delaware, MedStar Washington Hospital Center, MedStar Heart & Vascular Institute

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Simons Foundation, National Institute of General Medical Sciences