Changes and roles of intestinal fungal microbiota in coronary heart disease complicated with nonalcoholic fatty liver disease.
Year: 2020
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Patients who suffered coronary heart disease (CHD) complicated with non-alcoholic fatty liver disease (NAFLD) were reported to have worse cardiac function and clinical outcomes than patients with CHD only. The mechanism was unclear. Previous study focused on the metabolism and showed it could be regulated by the microbiota. Few studies related to fungi. We aimed to investigate the characteristics of intestinal fungal microbiota in CHD patients complicated with NAFLD (CHD-NAFLD). METHODS: 72 People were recruited and equally divided into three groups, including CHD patients (without NAFLD), CHD-NAFLD patients, and healthy controls (HCs). Fecal samples were collected. The Illumina sequencing of the internal transcribed spacer 3-4 rRNA was applied. RESULTS: . CONCLUSIONS: These changes of intestinal fungal microbiota in CHD-NAFLD patients may be important factors affecting the degree of metabolic disorder. But there are few reports on these fungi. More studies are needed to confirm the effects of these fungi on human.
Source: PubMed
Authors: Jun Xu, Yiwen Zhang, Xuemei Wang, Xinhua Ren, Yulan Liu
Institution: Peking University People's Hospital
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3049604722