Year: 2020
Type: article
Abstract: : The immune-suppressive effects of cannabidiol (CBD) are attributed to the modulation of essential immunological signaling pathways and receptors. Mechanistic understanding of the pharmacological effects of CBD emphasizes the therapeutic potential of CBD as a novel immune modulator. Studies have observed that the antagonists of CB 1 and CB 2 receptors and transient receptor potential vanilloid 1 reverse the immunomodulatory effects of CBD. CBD also inhibits critical activators of the Janus kinase/signal transducer and activator of transcription signaling pathway, as well as the nucleotide-binding oligomerization domain-like receptor signaling pathway, in turn decreasing pro-inflammatory cytokine production. Furthermore, CBD protects against cellular damage incurred during immune responses by modulating adenosine signaling. Ultimately, the data overwhelmingly support the immunosuppressive effects of CBD and this timely review draws attention to the prospective development of CBD as an effective immune modulatory therapeutic. Keywords: cannabidiol, CBD, immune modulation, CB 1 and CB 2 receptors, TRPV1, JAK/STAT, inflammasome
Source: ImmunoTargets and Therapy
DOI: 10.2147/itt.s263690
Institution: University of Miami
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,320
Funders: National Science Foundation, University of Miami, National Institutes of Health, Leonard M. Miller School of Medicine, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of General Medical Sciences, Division of Chemical, Bioengineering, Environmental, and Transport Systems, Division of Chemistry
Awards: Protein displayed spores and spore ghosts platforms for detection and biotransformation, G1309373569, G140693692, G2271813062, G2294200398, G2990170496, G4011594687, G5406299804, Sensitive Detection of Viral Persistency Using Bioluminescent Stem-Loop Probes, G7068466250, G7276077397, G7489364020, Nano-delivery of methanandamide across BBB to block cannabinoid induced effects in HIV-1 infection, Role of the BBB in HIV brain infection during methamphetamine abuse, G9000117651, G9000162161, G9000206071, G9000299556, G9000300333, G9000310908, EAGER SitS:Smart Long-Lived Biosensors for Soil Monitoring Using Engineered Spores
OpenAlex ID: W3049751096