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Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells

Year: 2020

Type: article

Abstract: A hybrid gene delivery platform, micro Cell Vesicle Technology (mCVT), produced from the fusion of plasma membranes and cationic lipids, is presently used to improve the transfection efficiency of hard-to-transfect (HTT) cells. The plasma membrane components of mCVTs impart specificity in cellular uptake and reduce cytotoxicity in the transfection process, while the cationic lipids complex with the genetic material and provide structural integrity to mCVTs.

Source: Nanoscale

DOI: 10.1039/d0nr03784b

Authors: Yi-Hsuan Ou, Shui Zou, Wei Jiang Goh, Suet Yen Chong, Gopalakrishnan Venkatesan, Matthias G. Wacker, Gerrit Storm, Jiong-Wei Wang, Bertrand Czarny, Giorgia Pastorin, Esther C. Y. Woon

Institutions: National University of Singapore, National University Heart Centre Singapore, National University Health System, Utrecht University, University of Twente, National University Hospital, Nanyang Technological University, UCL School of Pharmacy, University College London

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National University of Singapore, Ministry of Education - Singapore, Nanyang Technological University, Ministry of Education, India, National Medical Research Council

Awards: G2770816517, G4499333627, G5042528237, G7836691446, G8140717458

OpenAlex ID: W3055457730

FWCI: 0.357

Cites: 40

Cited by: 6

Related to: 10