Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research
Year: 2020
Type: article
Abstract: The recently developed new genome-editing technologies, such as the CRISPR/Cas system, have opened the door for generating genetically modified nonhuman primate (NHP) models for basic neuroscience and brain disorders research. The complex circuit formation and experience-dependent refinement of the human brain are very difficult to model in vitro, and thus require use of in vivo whole-animal models. For many neurodevelopmental and psychiatric disorders, abnormal circuit formation and refinement might be at the center of their pathophysiology. Importantly, many of the critical circuits and regional cell populations implicated in higher human cognitive function and in many psychiatric disorders are not present in lower mammalian brains, while these analogous areas are replicated in NHP brains. Indeed, neuropsychiatric disorders represent a tremendous health and economic burden globally. The emerging field of genetically modified NHP models has the potential to transform our study of higher brain function and dramatically facilitate the development of effective treatment for human brain disorders. In this paper, we discuss the importance of developing such models, the infrastructure and training needed to maximize the impact of such models, and ethical standards required for using these models.
Institutions: Broad Institute, McGovern Institute for Brain Research, Stanley Center for Psychiatric Research, Massachusetts Institute of Technology, University of Pennsylvania, Stanford University, Keio University, RIKEN Center for Brain Science, German Primate Center, University of Göttingen, University of Cambridge, Gatsby Charitable Foundation, Chinese Academy of Sciences, Center for Excellence in Brain Science and Intelligence Technology, State Key Laboratory of Neuroscience, Stanford Medicine, University of California, Davis
Language: English
Topic: Primate Behavior and Ecology
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Funders: Massachusetts Institute of Technology, National Academies of Sciences, Engineering, and Medicine, Broad Institute, National Institutes of Health, Stanley Center for Psychiatric Research, Broad Institute, National Institute on Aging, National Institute of Mental Health, NIH Office of the Director, National Institute of Neurological Disorders and Stroke, California National Primate Research Center
Awards: A Nonhuman Primate Model of Early Alzheimer's Disease Pathogenesis, Developmental origins of mental illness: evolution and reversibility, Immune Mechanisms Underlying Age-Related Neurodegeneration in HIV Infection, G21273325, G218385303, G2625269836, G2833584570, Interaction between epilepsy and AD: novel therapeutic strategies, G4609058222, A Molecular and Cellular Atlas of the Marmoset Brain, G5590726179, G6278318099, Knockin marmoset reporters for non-invasive measuring of genome-editing efficiency, G791781759, Quantifying synaptic density loss in a monkey model of early Alzheimer's Disease, G9000250825, California National Primate Research Center
OpenAlex ID: W3077433246