The Effects of Stiffness, Fluid Viscosity, and Geometry of Microenvironment in Homeostasis, Aging, and Diseases: A Brief Review
Year: 2020
Type: review
Abstract: Cells sense biophysical cues in the micro-environment and respond to the cues biochemically and biophysically. Proper responses from cells are critical to maintain the homeostasis in the body. Abnormal biophysical cues will cause pathological development in the cells; pathological or aging cells, on the other hand, can alter their micro-environment to become abnormal. In this minireview, we discuss four important biophysical cues of the micro-environment-stiffness, curvature, extracellular matrix (ECM) architecture and viscosity-in terms of their roles in health, aging, and diseases.
DOI: 10.1115/1.4048110
Institution: Johns Hopkins University
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: bronze
Awards: Acquisition of a Cyfuse Regenova 3D Bio-printer, Exploring the effects of extracellular fluid viscosity on cell migration and cancer metastasis, Tension-Sensitive Drug Release System to Enhance Targeting Selectivity, Engineered Fibroblasts as Cell Therapy to Treat Colorectal Cancer via Tumor Stroma Stabilization, Translational Aging Research Training Program
OpenAlex ID: W3079438341