Work

[Ketamine as an anesthetic, analgesic and anti-depressant].

Year: 2020

Type: article

Abstract: BACKGROUND: Treatment-resistance occurs in about 30% of patients with depression. Therefore, there is an urgent need to identify new treatment strategies. Ketamine, originally developed as an anesthetic, is studied and applied as treatment for patients with treatment-resistant depression. AIM: A critical review of the current use of ketamine as an antidepressant. METHOD: Literature study. RESULTS: Ketamine is a proven effective acute antidepressant. However, limited information is available about maintenance of effect of ketamine, potential risks of repeated administration, and different routes of administration and treatment schedules. CONCLUSION: Additional research on ketamine as an antidepressant is needed. Meanwhile, (off-label) treatment should only be applied after careful patient selection and under close monitoring.

Source: PubMed

Authors: S Y Smith-Apeldoorn, J K E Veraart, J Kamphuis, J J Breeksema, W van den Brink, M Aan Het Rot, R A Schoevers

Language: Dutch

Topic: Treatment of Major Depression

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3080489261

FWCI: 0.695

Cites:

Cited by: 7

Related to: 10