Adiposity and cardiovascular outcomes in three‐year‐old children of participants in UPBEAT , an RCT of a complex intervention in pregnant women with obesity
Year: 2020
Type: article
Abstract: BACKGROUND: Maternal obesity is associated with offspring cardiometabolic risk. UPBEAT was a randomised controlled trial of an antenatal diet and physical activity intervention in 1555 women with obesity. The intervention was associated with lower gestational weight gain, healthier diet and metabolic profile in pregnancy, and reduced infant adiposity at six months. OBJECTIVE: We have investigated whether the UPBEAT intervention influenced childhood cardiometabolic outcomes or was associated with sustained improvements in maternal lifestyle 3-years after delivery. METHODS: In UPBEAT mother-child dyads at the 3-year follow-up, we assessed childhood blood pressure, resting pulse rate, and adiposity (body mass index, skinfold thicknesses, body fat, waist and arm circumferences) and maternal diet, physical activity, and anthropometry. RESULTS: 514 three-year-old children attended the appointment (49% intervention, 51% standard care). There was no difference in the main outcome of interest, subscapular skinfold thickness, between the trial arms (-0.30 mm, 95% confidence interval: -0.92, 0.31). However, the intervention was associated with a lower resting pulse rate (-5 bpm [-8.41, -1.07]). There was also a non-significant lower odds of overweight/obesity (OR 0.73; 0.50, 1.08). Maternal dietary improvements observed in the UPBEAT trial, including glycaemic load and saturated fat were maintained 3-years postpartum. CONCLUSION: This study has demonstrated that an antenatal dietary and physical activity intervention in women with obesity is associated with lower offspring pulse rate and sustained improvement in maternal diet. Whilst larger than previous cohorts, there remains potential for bias from attrition and these findings require validation in future cohorts.
Source: Pediatric Obesity
DOI: 10.1111/ijpo.12725
Authors: Kathryn V. Dalrymple, Florence A. S. Tydeman, Paul D. Taylor, Angela C. Flynn, Majella O'Keeffe, Annette L. Briley, Paramala Santosh, Louise Hayes, Stephen C. Robson, Scott M. Nelson, Naveed Sattar, Melissa K. Whitworth, Harriet L. Mills, Claire Singh, Paul T. Seed CStat, Sara L. White, Deborah A. Lawlor, Keith M. Godfrey, Lucilla Poston
Institutions: King's College London, University of Strathclyde, Newcastle University, Glasgow Royal Infirmary, NIHR Bristol Biomedical Research Centre, University of Glasgow, British Heart Foundation, St Mary's Hospital, University of Bristol, MRC Integrative Epidemiology Unit, University Hospital Southampton NHS Foundation Trust, NIHR Southampton Biomedical Research Centre, MRC Lifecourse Epidemiology Unit, University of Southampton
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
Funders: University Hospitals Bristol NHS Foundation Trust, National Institute for Health and Care Research, British Heart Foundation, Guy's and St Thomas' Charity, King's College London, European Commission, University of Bristol, King's Health Partners, Tommy's, National Institute for Health Research Southampton Biomedical Research Centre, National Institutes of Health, Medical Research Council, Biotechnology and Biological Sciences Research Council, Economic and Social Research Council, Erasmus+, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, H2020 European Research Council
Awards: The UPBEAT RCT mother-child study. Stratifying and treating obese pregnant women to prevent adverse pregnancy, perinatal and longer term outcomes., G1093531541, G1112915806, G1277089031, Reproductive and cardio-metabolic health, Programme 1: Musculoskeletal health in later life, G1563105402, G1652070670, G1795554050, G2036275677, G2125390887, A study to determine whether associations between micronutrient status and susceptibility to oxidative stress play a role in the aetiology of pre-eclampsia, G2473961061, G2819467015, G2838213439, G2973790809, Interdisciplinary Research Network on Early Adversity & Later Life Reversibility, Mechanisms of renal ageing in a rodent model of developmental programming arising from early catch-up growth, Effect of a complex lifestyle intervention in pregnant obese women on childhood cardiovascular function, G3207356259, G3424013768, NIHR Senior Investigator Award, G3601192221, Improving pregnancy outcome in obese women, G389277099, G393177772, Early Nutrition eAcademy Southeast Asia, G4418645022, G4547270151, NIHR Senior Investigator Award, G4758008823, Capacity Building to Improve Early Nutrition and Health in South Africa, Programme 3: Early development and risk of adult musculoskeletal disease, G4964355645, Research Network on Later-Life Interventions to Reverse Effects of Early Life Adversity, G5260012927, G5439784885, G5605571342, NIHR Senior Investigator Award, G5702163051, Epigenetic biomarkers and determinants of cardiovascular risk in children, G6251221280, G6470444756, G6910425605, Effects of maternal gestational adiposity on fetal development and perinatal, postnatal and next generation health., G7148818572, G7264751730, Metabolomic and Epigenomic Mechanisms in Developmental Overnutrition., G740803340, G7643966348, G7689853932, Nutrition, Development and Lifelong Health: Studies in European Populations, G8502142660, G8537530744, Long-term effects of early nutrition on later health, The influence of a complex intervention of diet and physical activity in obese pregnant women on the cardiometabolic phenotype of old children: analysis of the UPBEAT trial
OpenAlex ID: W3080733991