Work

The Sensor Kinase QseC Regulates the Unlinked PmrA Response Regulator and Downstream Gene Expression in Francisella

Year: 2020

Type: article

Abstract: The disease tularemia is caused by the highly infectious Gram-negative pathogen Francisella tularensis . This bacterium encodes few regulatory factors (e.g., two-component systems [TCS]). PmrA, required for intramacrophage survival and virulence in the mouse model, is encoded by an orphan TCS response regulator gene. It is unclear how PmrA is responsive to environmental signals to regulate loci, including the PmrA-repressed gene priM . We identify an orphan sensor kinase (QseC) that is required for priM repression and further explore both environmental signals that might regulate the QseC-PmrA TCS and the function of PriM.

Source: Journal of Bacteriology

DOI: 10.1128/jb.00321-20

Authors: Ky Van Hoang, James Fitch, Peter White, Nrusingh P. Mohapatra, John S. Gunn

Institutions: Nationwide Children's Hospital, Abigail Wexner Research Institute, The Ohio State University

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Awards: G2278028631, Regulation of Francisella virulence by sRNAs