Year: 2020
Type: review
Abstract: Stroke remains the leading cause of adult disability. Post-stroke neurogenesis contributes to functional recovery. As an intrinsic neurorestorative process, it is important to elucidate the molecular mechanism underlying stroke-induced neurogenesis and to develop therapies designed specifically to augment neurogenesis. Epigenetic mechanisms include DNA methylation, histone modification and its mediation by microRNAs and long-non-coding RNAs. In this review, we highlight how epigenetic factors including DNA methylation, histone modification, microRNAs and long-non-coding RNAs mediate stroke-induced neurogenesis including neural stem cell self-renewal and cell fate determination. We also summarize therapies targeting these mechanisms in the treatment of stroke.
DOI: 10.3390/ijms21176179
Institutions: Henry Ford Health, Oakland University
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,112
Awards: Translational study of miR-146a gene therapy for diabetic peripheral neuropathy, G3364314664, Exosome therapy for acute stroke with large artery occlusion, Vasculotide promotes cognitive improvement in rats with vascular dementia, G6871099636, MicroRNAs and neurogenesis after stroke, Exosomes and platinum-induced peripheral neuropathy, G7908017237, miR-17-92 exosome treatment of stroke, G928140563
OpenAlex ID: W3080974587