Work

Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

Year: 2020

Type: article

Abstract: We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.

Source: eLife

DOI: 10.7554/elife.58042

Authors: Javier Díaz-Alonso, Wade Morishita, Salvatore Incontro, Jeffrey Simms, Julia Holtzman, Michael Gill, Lennart Mucke, Robert C Malenka, Roger A Nicoll

Institutions: University of California, San Francisco, University of California, Irvine, Stanford Medicine, Stanford University, Gladstone Institutes

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,500

Funder: National Institute of Mental Health

Awards: G1556744109, G184328388, AMPA Receptor Subunits and Plasticity, G5799761610, G6571872535

OpenAlex ID: W3081036817

FWCI: 2.591

Cites: 34

Cited by: 37

Related to: 10