Year: 2020
Type: article
Abstract: Introduction Glucose hypometabolism and tau formation are key features of Alzheimer's disease (AD). Less is known about the relationship between fasting glucose and regional tau accumulation. Methods Cerebrospinal fluid (CSF) glucose was linearly regressed on regional tau (flortaucipir) among 169 Alzheimer's Disease Neuroimaging Initiative (ADNI3) participants. Flortaucipir uptake was examined by Braak stages and regions of interest (ROIs). Interactions were explored between CSF glucose and AD risk factors including regional amyloid beta (Aβ), sex, Apolipoprotein E ε4 ( APOE ε4) status, AD parental family history (AD FH), and cognitive impairment (CI). Results Interactions found higher CSF glucose tracked less tau in ROIs or Braak stages I/II (women, APOE ε4+, regional Aβ), III/IV (AD FH+, regional Aβ), and V/VI (AD FH+). CI drove Braak III‐VI associations. Discussion Among women and APOE ε4 carriers, higher CSF glucose tracked less early‐stage tau. Higher CSF glucose may reflect compensation against tau spreading in CI, Aβ+, or AD FH+.
DOI: 10.1002/trc2.12080
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,200
Funders: U.S. Department of Defense, Alzheimer's Association, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, Biogen, University of Southern California, F. Hoffmann-La Roche, Meso Scale Diagnostics, Alzheimer's Disease Neuroimaging Initiative, BioClinica, Novartis Pharmaceuticals Corporation, Iowa State University, Northern California Institute for Research and Education, Eisai, Servier, H. Lundbeck A/S, IXICO, National Institutes of Health, Genentech, Canadian Institutes of Health Research, National Institute on Aging
Awards: G1012222616, G104586243, G1298807586, G1554142629, Insulin Resistance, Biomarkers of Brain Function, and Intermittent Calorie Restriction, G1593117279, G1650819308, Wake Forest Alzheimer's Disease Core Center, G1880935189, G2100670906, G2152643862, G2189010064, G2340207221, G2400738173, G2423387114, G2471646051, G2522063444, G2835601961, G29951154, G3131374986, G3216574877, G3553156159, Genetic Variation in Sirtuins and Associations with Memory & Brain Atrophy, G3710456697, G3752451908, G3870774570, G3908963977, G3966393351, G4119534169, G43180419, G4475667458, G4501223628, G4800177743, G5207404921, G5209990037, G528601746, G5324093878, G5365730499, G5654639750, Alzheimer's Disease Neuroimaging Initiative, G5740349702, G5850682332, G613619302, G6173816828, G6210868510, G6371410416, G6412110892, G6447063303, G6719828067, G6792506723, G6899163935, G6948409098, G72415811, G7298697282, G764699806, G7799614282, G781725486, G8228018387, G8281378126, G8373615653, G839208290, G845791370, G8852128998, G8895907669, G8897063270, G8957659042
OpenAlex ID: W3081157549