Work

Neuropharmacological Effects of Mesaconitine: Evidence from Molecular and Cellular Basis of Neural Circuit

Year: 2020

Type: article

Abstract: Mesaconitine (MA), a diester-diterpenoid alkaloid in aconite roots, is considered to be one of the most important bioactive ingredients. In this review, we summarized its neuropharmacological effects, including analgesic effects and antiepileptiform effects. Mesaconitine can act on the central noradrenergic system and the serotonin system; behaving like the norepinephrine reuptake inhibitors and tricyclic antidepressants that increase norepinephrine levels in stress-induced depression. Therefore, the possible perspectives for future studies on the depression of MA were also discussed as well. The pharmacological effect of MA on depression is worthy of further study.

Source: Neural Plasticity

DOI: 10.1155/2020/8814531

Authors: Zhihui Sun, Limin Yang, Lihong Zhao, Ranji Cui, Wei Yang

Institutions: Jilin Agricultural University, Jilin University, Second Affiliated Hospital of Jilin University

Language: English

Topic: Plant-based Medicinal Research

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,830