Work

Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases

Year: 2020

Type: article

Abstract: This review discusses how lipophagy and cytosolic lipolysis degrade cellular lipids, as well as how these pathway ys communicate, how they affect lipid metabolism and energy homeostasis in cells and how their dysfunction affects the pathogenesis of lipid storage and lipid metabolism diseases. Answers to these questions will likely uncover novel strategies for the treatment of aforementioned human diseases, but, above all, will avoid destructive effects of high concentrations of lipids-referred to as lipotoxicity-resulting in cellular dysfunction and cell death.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms21176113

Authors: Anna Kloska, Magdalena Węsierska, Marcelina Malinowska, Magdalena Gabig-Cimińska, Joanna Jakóbkiewicz-Banecka

Institutions: University of Gdańsk, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Polish Academy of Sciences

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,112