Year: 2018
Type: article
Study design: Observational Study
Abstract: Title: Genetic variation at the IL1RAP locus and its influence on late-life depression in a population-based sample in\nGothenburg, Sweden\nAuthor: David Mårdensjö\nSupervisor: Anna Zettergren, PhD\nIntroduction: Recently, it was discovered in two large genome-wide association studies that there\nis an association between genetic variation in the gene interleukin-1 receptor associated protein\n(IL1RAP) and Alzheimer’s disease traits. Inflammation has been implicated as an important pathomechanism\nfor both dementia and late-life depression (LLD). However, the association between\nILRAP and LLD have to our knowledge never been specifically investigated\nAim: The aim of this study was to examine the possible association between LLD and genetic\nvariation in, or in close vicinity, to the gene IL1RAP in a population-based sample of older individuals.\nMethods: Genotype data were available for 3,559 study participants from four cohorts of the longitudinal\ngerontological and geriatric population studies in Gothenburg, and 2715 were included\nin the statistical analysis after exclusion. All participants took part in a neuropsychiatric and neuropsychological\nexamination. The relation between genotype and depression diagnoses as well as\nwith the severity of depressive symptoms (measured with MADRS-score) were investigated.\nResults: The main findings were associations between the common homozygotes of rs3773976,\nrs12053868, rs3773970 and rs4687151, and females with major depression, with the strongest\nbeing for rs3773970 (OR: 2.01 [95% CI: 1.14-3.56], p=0.016) in the logistic regression model adjusted\nfor APO e4-status and age at first interview. Significant associations between the common\nhomozygotes of two of these polymorphisms (rs3773976 and rs3773970) and increased MADRSscore\nwere also found in the linear regression model using the same covariates. No association\nwas found for rs9877502.\nConclusions: Our results indicate that genetic variation at the ILRAP locus may be of importance\nfor LLD. However, the effect size and study sample were small. The finding should be interpreted\nwith caution until replicated in additional samples of older indviduals.\nKey words: Late-life depression, gene, interleukin 1 receptor accessory protein
Author: David Mårdensjö
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3081974274