Work

Impact of anxiety and depression on progression to glaucoma among glaucoma suspects

Year: 2020

Type: article

Abstract: AIMS: To assess the impact of anxiety and depression in the risk of converting to glaucoma in a cohort of glaucoma suspects followed over time. METHODS: The study included a retrospective cohort of subjects with diagnosis of glaucoma suspect at baseline, extracted from the Duke Glaucoma Registry. The presence of anxiety and depression was defined based on electronic health records billing codes, medical history and problem list. Univariable and multivariable Cox proportional hazards models were used to obtain HRs for the risk of converting to glaucoma over time. Multivariable models were adjusted for age, gender, race, intraocular pressure measurements over time and disease severity at baseline. RESULTS: A total of 3259 glaucoma suspects followed for an average of 3.60 (2.05) years were included in our cohort, of which 911 (28%) were diagnosed with glaucoma during follow-up. Prevalence of anxiety and depression were 32% and 33%, respectively. Diagnoses of anxiety, or concomitant anxiety and depression were significantly associated with risk of converting to glaucoma over time, with adjusted HRs (95% CI) of 1.16 (1.01, 1.33) and 1.27 (1.07, 1.50), respectively. CONCLUSION: A history of anxiety or both anxiety and depression in glaucoma suspects was associated with developing glaucoma during follow-up.

Source: British Journal of Ophthalmology

DOI: 10.1136/bjophthalmol-2020-316617

Authors: Samuel Berchuck, Alessandro Jammal, Sayan Mukherjee, Tamara Somers, Felipe A Medeiros

Institutions: Duke University, Duke Medical Center

Language: English

Topic: Glaucoma and retinal disorders

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green