Efficacy of GBT440 to Left-Shift the Oxy-Hemoglobin Dissociation Curve in Healthy Individuals and Preserve Arterial Saturation During Submaximal Hypoxic Exercise
Year: 2018
Type: conference-paper
Abstract: Introduction: Numerous conditions can cause hypoxia-induced cardiopulmonary perturbations that are associated with the degree of arterial oxygen desaturation. Global Blood Therapeutics (GBT) has developed an allosteric modulator of hemoglobin (GBT440) that increases the affinity of hemoglobin for oxygen and left shifts the oxy-hemoglobin dissociation curve. Accordingly, this study investigated the efficacy of GBT440 to preserve arterial oxygen saturation while exercising during acute hypoxia.
Source: Griffith Research Online
Authors: Glenn M. Stewart, Troy J. Cross, Steven C. Chase, Michael J. Joyner, Timothy B. Curry, Jennifer Isautier, Josh Lehrer, NE Vlahakis, BD Johnson
Language: English
Topic: High Altitude and Hypoxia
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3082119630