A Phylogeny-Informed Proteomics Approach for Species Identification within the Burkholderia cepacia Complex
Year: 2020
Type: article
Abstract: Ancestral genetic exchange between members of many important bacterial pathogen groups has resulted in phylogenetic relationships better described as networks than as bifurcating trees. In certain cases, these reticulated phylogenies have resulted in phenotypic and molecular overlap that challenges the construction of practical approaches for species identification in the clinical microbiology laboratory. Burkholderia cepacia complex (Bcc), a betaproteobacteria species group responsible for significant morbidity in persons with cystic fibrosis and chronic granulomatous disease, represents one such group where network-structured phylogeny has hampered the development of diagnostic methods for species-level discrimination.
Source: Journal of Clinical Microbiology
DOI: 10.1128/jcm.01741-20
Institutions: National Institutes of Health, National Institutes of Health Clinical Center, National Heart, Lung, and Blood Institute, Johns Hopkins University, National Institute of Diabetes and Digestive and Kidney Diseases, University of Michigan, Michigan Medicine, National Institute of Allergy and Infectious Diseases
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3082275277