Sequence of Alzheimer disease biomarker changes in cognitively normal adults
Year: 2020
Type: article
Abstract: OBJECTIVE: To determine the ordering of changes in Alzheimer disease (AD) biomarkers among cognitively normal individuals. METHODS: C] benzothiazole tracer Pittsburgh compound B (PiB), MRI-based brain structures, and clinical/cognitive outcomes harmonized from 8 studies, collectively involving 3,284 cognitively normal individuals 18 to 101 years of age, were analyzed. The age at which each marker exhibited an accelerated change (called the change point) was estimated and compared across the markers. RESULTS: ratio, albeit not significantly different from that for PiB SUVR, occurred significantly earlier than that for CSF Tau, Ptau, MRI markers, and the cognitive composite. Adjusted analyses confirmed that accelerated changes in CSF Tau, Ptau, MRI markers, and the cognitive composite occurred at ages not significantly different from each other. CONCLUSIONS: Our findings support the hypothesized early changes of amyloid in preclinical AD and suggest that changes in neuronal injury and neurodegeneration markers occur close in time to cognitive decline.
Source: Neurology
Authors: Jingqin Luo, Folasade Agboola, Elizabeth Grant, Colin L. Masters, Marilyn S. Albert, Sterling C. Johnson, Eric M. McDade, Jonathan Vöglein, Anne M. Fagan, Tammie Benzinger, Parinaz Massoumzadeh, Jason Hassenstab, Randall J. Bateman, John C. Morris, Richard J. Perrin, Jasmeer Chhatwal, Mathias Jucker, Bernardino Ghetti, Carlos Cruchaga, Neill R. Graff-Radford, Peter R. Schofield, Hiroshi Mori, Chengjie Xiong
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G117713310, G1496489604, G1602390028, G2360966051, G2824222223, G2880069213, G40706755, G4427631003, G4610379609, Biomarkers of Cognitive Decline Among Normal Individuals: The Biocard Cohort, White matter degeneration: biomarkers in preclinical Alzheimer's Disease, PURCHASE OF A SIEMENS NEXT GENERATION PET/CT, Dominantly Inherited Alzheimer Network, G587293260, G6024075114, G6175344765, G631053645, Alzheimer's Disease Research Center, SV2A PET imaging in Alzheimer's Disease, Dominantly Inherited Alzheimer Network, NINDS CENTER CORE FOR BRAIN IMAGING, Preclinical AD Consortium, The Longitudinal Course of Imaging Biomarkers in People At Risk for Alzheimer’s Disease, Wisconsin Registry for Alzheimer's Prevention, Alzheimer's Disease Research Center, Johns Hopkins Alzheimer's Disease Research Center, Wisconsin Alzheimer's Disease Research Center, Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study
OpenAlex ID: W3082476700