Work

Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer

Year: 2020

Type: review

Abstract: Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinical outcomes and overall survival. Here, we review the epigenetic mechanisms of regulation involved in cell pathways disrupted in TNBC, with particular emphasis on dietary food components that may be exploited for the development of effective strategies for management of TNBC.

Source: Frontiers in Nutrition

DOI: 10.3389/fnut.2020.00159

Authors: Ornella I. Selmin, Micah G. Donovan, Barbara J. Stillwater, Leigh Neumayer, Donato F. Romagnolo

Institutions: University of Arizona, University of Arizona Cancer Center

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,490