Work

Clearance of amyloid‐beta with bispecific antibody constructs bound to erythrocytes

Year: 2020

Type: article

Abstract: We propose use of bispecific monoclonal antibody (mAb) complexes bound to erythrocytes to redress the lack of efficacy of anti-amyloid beta mAbs in Alzheimer's disease treatment. Our paradigm leverages erythrocyte complement receptor 1 to promote rapid and quantitative removal of amyloid beta from the circulation, and its subsequent removal from the brain as well.

Source: Alzheimer s & Dementia Translational Research & Clinical Interventions

DOI: 10.1002/trc2.12067

Authors: Ronald P. Taylor, Margaret A. Lindorfer, John P. Atkinson

Institutions: University of Virginia, Washington University in St. Louis

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,200