Work

Live In Vivo Imaging of Plasmodium Invasion of the Mosquito Midgut

Year: 2020

Type: article

Abstract: Malaria is one of the most devastating parasitic diseases in humans and is transmitted by anopheline mosquitoes. The mosquito midgut is a critical barrier that Plasmodium parasites must overcome to complete their developmental cycle and be transmitted to a new host. Here, we developed a new strategy to visualize Plasmodium ookinetes as they traverse the mosquito midgut and to follow the response of damaged epithelial cells by imaging live mosquitoes. Understanding the spatial and temporal aspects of these interactions is critical when developing novel strategies to disrupt disease transmission.

Source: mSphere

DOI: 10.1128/msphere.00692-20

Authors: Nathanie Trisnadi, Carolina Barillas-Mury

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,500