Work

Transport of nanoprobes in multicellular spheroids

Year: 2020

Type: article

Abstract: The efficient delivery of drugs to cells depends on their diffusion through the extracellular matrix (ECM) of tissues. Here we present a study on the diffusion of nanoprobes of radius from 1 nm to over 100 nm in the ECM of spheroids of three cell types (HeLa, MCF-7 and fibroblasts). We quantified the nanoparticle transport in the spheroids' proliferating zone. We determined the size-dependent viscosity of the ECM. We revealed that nanoobjects up to 10 nm in radius exhibited unobstructed diffusion in the ECM, regardless of the spheroid type. The presented length-scale dependent viscosity profiles for spheroids pave the way for advanced modelling of drug administration through tissues.

Source: Nanoscale

DOI: 10.1039/d0nr01986k

Authors: Marta Pilz, Karina Kwapiszewska, Tomasz Kalwarczyk, Grzegorz Bubak, Dominika Nowis, Robert Hołyst

Institutions: Institute of Physical Chemistry, Polish Academy of Sciences, Medical University of Warsaw, University of Warsaw

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Narodowe Centrum Nauki, Narodowym Centrum Nauki