Work

Histone deacetylase inhibitors promote epithelial-mesenchymal transition in Hepatocellular Carcinoma via AMPK-FOXO1-ULK1 signaling axis-mediated autophagy

Year: 2020

Type: article

Abstract: We demonstrated that HDIs triggers FOXO1-dependent autophagy, which ultimately promotes EMT, limiting the clinical outcome of HDI-based therapies. Our study suggests that the combination of an HDI and a FOXO1 inhibitor is an effective therapeutic strategy for the treatment of HCC.

Source: Theranostics

DOI: 10.7150/thno.47045

Authors: Qiang Xiao, Hao Liu, Hong-Sheng Wang, Meng-Ting Cao, Xiao-Jun Meng, Ya-Li Xiang, Ya-Qin Zhang, Feng Shu, Qiu-Gui Zhang, Hong Shan, Guan-Min Jiang

Institutions: Fifth Affiliated Hospital of Sun Yat-sen University, Guangzhou Medical University Cancer Hospital, Guangzhou Medical University, Sun Yat-sen University, The First People's Hospital of Changde, First Affiliated Hospital of University of South China, University of South China

Language: English

Topic: Histone Deacetylase Inhibitors Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W3082690217

FWCI: 2.041

Cites: 45

Cited by: 40

Related to: 10