Work

Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity

Year: 2020

Type: article

Abstract: , at least in part, by reducing astrocytic GLAST/GLT-1. Thus, YY1 might be a potential target for treatment of Mn toxicity and other neurological disorders associated with dysregulation of GLAST/GLT-1.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.ra120.015552

Authors: Edward Pajarillo, James Johnson, Asha Rizor, Ivan Nyarko-Danquah, Getinet Adinew, Julia Bornhorst, Michael Stiboller, Tania Schwerdtle, Deok-Soo Son, Michael Aschner, Eunsook Lee

Institutions: Florida Agricultural and Mechanical University, University of Wuppertal, University of Potsdam, Meharry Medical College, Albert Einstein College of Medicine

Language: English

Topic: Heavy Metal Exposure and Toxicity

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: National Cancer Institute, National Institute of Environmental Health Sciences, National Institute on Minority Health and Health Disparities

Awards: G1648296056, G172142613, G3752289998, Roles of proinflammatory chemokines linking obesity and breast cancer, G497747834, Genetic Modulation of MeHg-Induced Oxidative Stress in the Developing Brain, FAMU Center for Health Disparities Research, Mechanisms of Manganese Neurotoxicity, Mechanisms associated with neuroprotection from Mn-induced neurotoxicity.

OpenAlex ID: W3083145782

FWCI: 2.803

Cites: 97

Cited by: 51

Related to: 10