Work

Polygenic architecture informs potential vulnerability to drug-induced liver injury

Year: 2020

Type: article

Source: Nature Medicine

DOI: 10.1038/s41591-020-1023-0

Authors: Masaru Koido, Eri Kawakami, Junko Fukumura, Yui Noguchi, Momoko Ohori, Yasunori Nio, Paola Nicoletti, Guruprasad P. Aithal, Ann K. Daly, Paul B. Watkins, Hisashi Anayama, Yvonne Dragan, Tadahiro Shinozawa, Takanori Takebe

Institutions: Yokohama City University, Takeda (Japan), Icahn School of Medicine at Mount Sinai, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham Biomedical Research Centre, Newcastle University, University of North Carolina at Chapel Hill, Takeda (United States), Tokyo Medical and Dental University, Cincinnati Children's Hospital Medical Center, University of Cincinnati

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: New York Stem Cell Foundation, Cincinnati Children's Hospital Medical Center, Takeda Science Foundation, Takeda Pharmaceutical Company, Health Resources in Action, Japan Agency for Medical Research and Development, UK Research and Innovation, Mitsubishi Foundation, Takeda Oncology, Medical Research Council, Japan Society for the Promotion of Science, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G166906552, Modeling monogenic steatohepatitis using human liver organoids, Engineering multi-organs in a dish, G4609447660, G6373447378, Inter-cellular RNA transfer-driven reprogramming

OpenAlex ID: W3083200957

FWCI: 10.69

Cites: 45

Cited by: 80

Related to: 10