Work

The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells

Year: 2020

Type: article

Source: Science Immunology

DOI: 10.1126/sciimmunol.abb1455

Authors: Kazuko Miyazaki, Hitomi Watanabe, Genki Yoshikawa, Kenian Chen, Reiko Hidaka, Yuki Aitani, Kai Osawa, Rie Takeda, Yotaro Ochi, Shizue Tani-ichi, Takuya Uehata, Osamu Takeuchi, Koichi Ikuta, Seishi Ogawa, Gen Kondoh, Yin C. Lin, Hiroyuki Ogata, Masaki Miyazaki

Institutions: Kyoto University, Kyoto University Institute for Chemical Research, Baylor Scott & White Research Institute, Karolinska Institutet, Institute for the Advanced Study of Human Biology, Kyoto University

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: closed

Funders: Japan Agency for Medical Research and Development, Ministry of Education, Culture, Sports, Science and Technology, Mochida Memorial Foundation for Medical and Pharmaceutical Research, Takeda Medical Research Foundation, Japan Society for the Promotion of Science

Awards: Elucidation of a novel posttranscriptional mechanism regulating early lymphopoiesis, The Regulome controls adaptive lymphocyte development and DNA recombinase Rag1/Rag2 expression, G4399644386, The transcriptional regulation by E-Id protein axis upon T cell activation and its cellular metabolism, Elucidation of the relationship between viral diversification and biological evolution, comprehensive studies on the molecular basis of early development and clonal evolution in cancer using advanced genomics., Analyisis of regulome through E/Id protein axis in Treg cells, Analysis of immune regulatory mechanisms mediated by mRNA metabolism, G8070359957, G8534409377, G8786264965

OpenAlex ID: W3083279246

FWCI: 2.724

Cites: 65

Cited by: 59

Related to: 10