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Abstract 2915: Preclinical characterization of PRT543, a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5), with broad antitumor activity in in vitro and in vivo models

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Year: 2020
Type: conference-abstract
Source: Cancer Research
DOI: 10.1158/1538-7445.am2020-2915
Authors: Neha Bhagwat, Yang Zhang, Hong Lin, Min Wang, Dave Rominger, Tom Emm, Divya Chugani-Mahtani, Dimitrios Angelis, Rupa Shetty, Raul Leal, William Gowen-MacDonald, Alexander Grego, Juan Luengo, Taghi Manshouri, Friederike Pastore, Ross L. Levine, Srdan Verstovsek, Bruce Ruggeri, Peggy Scherle, Kris Vaddi
Institutions: Prelude Therapeutics Incorporated (United States), The University of Texas MD Anderson Cancer Center, Memorial Sloan Kettering Cancer Center
Language: English

Topic: Cancer-related gene regulation
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
SDG: Good health and well-being

Open Access status: closed
OpenAlex ID: W3083485009
Cites:
Cited by: 8
Related to: 10
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