Work

Insulator Based Dielectrophoresis: Micro, Nano, and Molecular Scale Biological Applications

Year: 2020

Type: article

Abstract: Insulator based dielectrophoresis (iDEP) is becoming increasingly important in emerging biomolecular applications, including particle purification, fractionation, and separation. Compared to conventional electrode-based dielectrophoresis (eDEP) techniques, iDEP has been demonstrated to have a higher degree of selectivity of biological samples while also being less biologically intrusive. Over the past two decades, substantial technological advances have been made, enabling iDEP to be applied from micro, to nano and molecular scales. Soft particles, including cell organelles, viruses, proteins, and nucleic acids, have been manipulated using iDEP, enabling the exploration of subnanometer biological interactions. Recent investigations using this technique have demonstrated a wide range of applications, including biomarker screening, protein folding analysis, and molecular sensing. Here, we review current state-of-art research on iDEP systems and highlight potential future work.

Source: Sensors

DOI: 10.3390/s20185095

Authors: Prateek Benhal, David Quashie, Yoontae Kim, Jamel Ali

Institutions: Florida A&M University - Florida State University College of Engineering, National High Magnetic Field Laboratory, American Dental Association

Language: English

Topic: Microfluidic and Bio-sensing Technologies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,112

Funders: National Science Foundation, National Cancer Institute