Work

Rhythm dynamics of the aging heart: an experimental study using conscious, restrained mice

Year: 2020

Type: article

Abstract: We have investigated age-associated alterations of heart rate properties in mice using conscious electrocardiographic recordings. Our findings support the notion that aging is coupled with altered sympathovagal balance with consequences on heart rate variability. Moreover, by using a genetically engineered mouse line, we provide evidence that sodium channels modulate heart rate and its age-related adaptations.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00379.2020

Authors: Martina Comelli, Marianna Meo, Daniel O. Cervantes, Emanuele Pizzo, Aaron Plosker, Peter J. Mohler, Thomas J. Hund, Jason T. Jacobson, Olivier Meste, Marcello Rota

Institutions: New York Medical College, Inserm, Electrophysiology and Heart Modeling Institute, Centre de Recherche Cardio-Thoracique de Bordeaux, The Ohio State University Wexner Medical Center, The Ohio State University, Westchester Medical Center, Centre National de la Recherche Scientifique, Université Côte d'Azur, Laboratoire d'Informatique, Signaux et Systèmes de Sophia Antipolis

Language: English

Topic: Heart Rate Variability and Autonomic Control

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Heart Association, National Institutes of Health, National Institute on Aging

Awards: Myocyte Repolarization and Cardiac Dysfunction with Age, Notch Signaling and Window of Opportunity for the Remodeling of the Infarcted Heart

OpenAlex ID: W3083729920

FWCI: 1.116

Cites: 63

Cited by: 17

Related to: 10