Work

The analysis of anxiety- and depression-related behaviors in neuropathic pain of mice - possible involvement of brain inflammation

Year: 2018

Type: article

Abstract: Back ground: Several reports have demonstrated a frequent association of chronic pain in humans with affective disorders, such as anxiety and depression. However, it is entirely unclear what mechanisms are involved. There is an intricate communication between the immune system and the central nervous system, and inflammation has been considered a common mediator of pain-depression comorbidity. High-mobility group box 1 protein (HMGB1) has gained much attention as an important player in innate immune responses and a modulating factor in several inflammatory diseases. Microglia activation is known to play critical roles in development of both chronic pain and depression. The current study examined characteristics of anxiety- and depression-related behaviors, and the change of HMGB1 and microglial activity in neuropathic pain of mice.

Source: Proceedings for Annual Meeting of The Japanese Pharmacological Society

DOI: 10.1254/jpssuppl.wcp2018.0_po2-2-15