Work

Restoration of RNA helicase DDX5 suppresses hepatitis B virus (HBV) biosynthesis and Wnt signaling in HBV-related hepatocellular carcinoma

Year: 2020

Type: article

Abstract: DDX5 is a negative regulator of Wnt signaling and hepatocyte reprogramming in HCCs. Restoration of DDX5 levels by miR17~92 / miR106b~25 antagomirs in HBV-infected patients can be explored as both antitumor and antiviral strategy.

Source: Theranostics

DOI: 10.7150/thno.49629

Authors: Saravana Kumar Kailasam Mani, Bingyu Yan, Zhibin Cui, Jiazeng Sun, Sagar Utturkar, Adrien Foca, Nadim Fares, David Durantel, Nadia Lanman, Philippe Merle, Majid Kazemian, Ourania Andrisani

Institutions: Purdue University West Lafayette, Centre National de la Recherche Scientifique, Inserm, Centre de Recherche en Cancérologie de Lyon, Lyon 1 Université, Hôpital de la Croix-Rousse, Hospices Civils de Lyon

Language: English

Topic: Hepatitis B Virus Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

Funders: Walther Cancer Foundation, Purdue University, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources

Awards: G2174458628, G2691256994, Indiana Clinical and Translational Science Institute (UL1), G3934584299, G41481329, G4748153501, Cancer Center Support Grant, G5674943387, G572954382, G7157771264, G7326577045, SOMATOSTATIN GENE EXPRESSION--FUNCTIONAL DOMAINS OF CREB, G8391742309, G9000039928, G9000315265

OpenAlex ID: W3083963129

FWCI: 4.296

Cites: 71

Cited by: 45

Related to: 10