Work

Discovery of novel antimalarial (s) using high throughput screening and combinatorial chemistry

Year: 2018

Type: article

Abstract: Introduction: Malaria is one of the major global health concern. Prompt proliferation of drug resistant malaria parasites and finite available drugs - increase the urgency to develop novel antimalarial compounds. Hemozoin formation through heme detoxification is an escape mechanism of blood stage malaria parasite and considered as promising target for antimalarial drugs. Previously 9,600 compounds with various structural diversity from >200,000 compounds at University of Tokyo library were screened where 224 compounds were identified as hemozoin inhibitors after an initial in vitro anti-hemozoin high throughput screening. In this research, we advanced our anti-hemozoin based antimalarial drug development.

Source: Proceedings for Annual Meeting of The Japanese Pharmacological Society

DOI: 10.1254/jpssuppl.wcp2018.0_po2-11-9

Authors: Farhana Mosaddeque, Shusaku Mizukami, Awet A Teklemichael, Satoshi Mizuta, Yoshimasa Tanaka, Mayumi Taniguchi, Michiko Fukuda, Nobuyuki Kobayashi, Nguyen T Huy, Kenji Hirayama

Institutions: Nagasaki University, Institute of Tropical Medicine, Nagasaki University

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W3084251295

FWCI:

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