Year: 2020
Type: review
Abstract: H2 has shown anti-inflammatory and antioxidant ability in many clinical trials, and its application is recommended in the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed the surprising finding that H2 gas may protect the lungs and extrapulmonary organs from pathological stimuli in NCP patients. The potential mechanisms underlying the action of H2 gas are not clear. H2 gas may regulate the anti-inflammatory and antioxidant activity, mitochondrial energy metabolism, endoplasmic reticulum stress, the immune system, and cell death (apoptosis, autophagy, pyroptosis, ferroptosis, and circadian clock, among others) and has therapeutic potential for many systemic diseases. This paper reviews the basic research and the latest clinical applications of H2 gas in multiorgan system diseases to establish strategies for the clinical treatment for various diseases.
DOI: 10.1155/2020/8384742
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,680
Awards: G1282082443, G1328900800, G1372923893, G1920625089, G1929843997, G19762547, G2397704272, G243848227, 水凝胶载体移植造血干细胞治疗心肌梗死的新方法, G3713587377, G4009089751, G4162992566, 新型保存液SS-Ⅱ液通过Nrf2/HO-1/Ferroptosis信号轴发挥心肌保护功能的机制研究, G4440264609, G4578640218, G4812808795, G4827839812, G4832398729, G4942157497, G5063549464, G5624183911, G5774300643, G588842017, G600165546, G606516273, G631185176, G6339774437, G6479579778, G6852470338, G6994916474, G7088794071, G7215419555, G7718836953, G8193227809, G8689805540, G8755559316, G8893855548, G8902422662
OpenAlex ID: W3084277555