Work

[Effects of different materials for partial sciatic nerve ligation on glial cell activation in rat models of chronic constriction injury].

Year: 2020

Type: article

Abstract: OBJECTIVE: To compare the effects of different materials for partial sciatic nerve ligation on glial cell activation in the spinal cord in a rat model of chronic constriction injury (CCI). METHODS: =14). The mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) of the rats were detected at 3, 7, 11 and 15 days after the operation. The changes in the sciatic nerve, the activation of spinal cord glial cells and the expression of inflammatory factors were observed using Western blotting and RT-PCR. RESULTS: < 0.05). CONCLUSIONS: The CCI models established by partial sciatic nerve ligation with silk suture and chromic catgut all show glial activation, and the inflammatory response is stronger in chromic catgut group.

Source: PubMed

DOI: 10.12122/j.issn.1673-4254.2020.08.20

Authors: Chen Wang, Peng Chen, Dongsheng Lin, Yi Chen, Zhibing Wu, Xingdong Lin

Institutions: Guangzhou University of Chinese Medicine, First Affiliated Hospital of Guangzhou University of Chinese Medicine, The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3084294174

FWCI:

Cites: 33

Cited by: 2

Related to: 10